CiteSpace58.R3 facilitated the analysis of psychological resilience literatures extracted from the Web of Science core Collection, spanning the period from January 1, 2010, to June 16, 2022.
The screening process yielded 8462 eligible pieces of literature. There has been a considerable upswing in research dedicated to psychological resilience over the last few years. The United States played a significant role, contributing greatly to this field. Robert H. Pietrzak, George A. Bonanno, Connor K.M., and their colleagues made a substantial and lasting impact.
It exhibits a citation frequency and centrality that is unmatched. Research hotspots related to psychological resilience during the COVID-19 pandemic concentrate on five key aspects: influencing factors, correlations with PTSD, resilience in special populations, and the molecular basis of resilience, including genetic factors. The most advanced and innovative research focus during the COVID-19 pandemic was psychological resilience.
The current investigation of psychological resilience trends and patterns, as described in this study, may provide insight into significant emerging challenges and opportunities for future research.
This investigation of psychological resilience research highlighted current trends and situations, with the aim of uncovering salient topics and inspiring novel research paths in this area.
Eliciting past memories, classic old movies and TV series (COMTS) can do so. Understanding nostalgia's impact on repeated viewing behaviors necessitates a theoretical framework centered on personality traits, motivation, and behavior.
To examine the relationship between personality characteristics, nostalgia, social bonds, and the intention to rewatch movies or TV series, an online survey was utilized (N=645).
The study's results demonstrated a correlation between individuals high in openness, agreeableness, and neuroticism, and an increased propensity for experiencing nostalgia, ultimately influencing their behavioral intention to repeatedly watch. In parallel, for agreeable and neurotic people, social connections play a mediating role in their behavioral intention regarding repeated viewing.
Individuals demonstrating openness, agreeableness, and neuroticism, as our findings indicate, are more susceptible to feelings of nostalgia, which then drives the intention of repeated viewing behavior. Moreover, social links act as an intermediary in the correlation between agreeableness and neuroticism and the intention to repeatedly watch.
The current paper introduces a groundbreaking digital-impulse galvanic coupling technique for high-speed data transfer across the skull to the cortex. Tethered wires connecting implants on the cortex and above the skull will be superseded by the proposed wireless telemetry, enabling a free-floating implant and consequently reducing brain tissue damage. Trans-dural wireless telemetry, to support fast data transfer, requires a broad channel bandwidth and a minuscule form factor to maximize minimal invasiveness. For examining the channel's propagation properties, a finite element model is developed, subsequently coupled with a channel characterization involving a liquid phantom and porcine tissue. The findings from the measurements of the trans-dural channel clearly show a substantial frequency response extending up to 250 MHz. This work also examines propagation loss resulting from micro-motion and misalignment. The results show a comparatively low sensitivity of the proposed transmission method to misalignment. A horizontal misalignment of 1 millimeter results in a loss increase of roughly 1 decibel. A miniature PCB module and a pulse-based transmitter ASIC have been designed and validated ex vivo using a 10-mm thick porcine tissue sample. Miniature in-body communication, using galvanic-coupled pulse technology, is presented in this work, demonstrating high speed, a data rate of up to 250 Mbps, remarkable energy efficiency of 2 pJ/bit, and a small module area of 26 mm2.
Solid-binding peptides (SBPs) have seen a proliferation of applications in materials science over the past many decades. Solid-binding peptides serve as a simple and versatile tool for the immobilization of biomolecules on a multitude of solid surfaces, representing a straightforward approach in non-covalent surface modification strategies. The biomolecule display properties of hybrid materials, particularly in physiological environments, can benefit from SBPs, resulting in tunable characteristics and minimal impact on the biomolecules' functionality. Due to the inherent features of SBPs, they are an attractive option for the manufacturing of bioinspired materials in diagnostic and therapeutic applications. Benefiting from the introduction of SBPs are biomedical applications such as drug delivery, biosensing, and regenerative therapies. We analyze recent publications concerning the utilization of solid-binding peptides and proteins in biomedical applications. Our efforts are directed towards applications where influencing the relationship between solid materials and biomolecules is indispensable. This review considers the characteristics of solid-binding peptides and proteins, examining sequence design principles and the fundamental aspects of their binding interactions. We then move to examine the application of these concepts to biocompatible materials, specifically focusing on calcium phosphates, silicates, ice crystals, metals, plastics, and graphene. The limited characterization of SBPs continues to present a challenge to their design and extensive use, but our review showcases the facile integration of SBP-mediated bioconjugation into multifaceted designs and nanomaterials with distinct surface chemistries.
The controlled release of growth factors on a bio-scaffold is the key to achieving successful critical bone regeneration in tissue engineering. Gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA), a novel focus in bone regeneration research, have seen enhanced mechanical properties through the addition of appropriate nano-hydroxyapatite (nHAP). Human urine-derived stem cell exosomes (USCEXOs) have also been shown to encourage bone formation in tissue engineering applications. A fresh GelMA-HAMA/nHAP composite hydrogel, envisioned as a drug delivery system, was conceived and explored in this study. A slow release of USCEXOs, encapsulated within the hydrogel, was designed to optimize the osteogenesis process. The GelMA-based hydrogel's characterization revealed an excellent controlled release performance, coupled with suitable mechanical properties. In vitro investigations revealed that the USCEXOs/GelMA-HAMA/nHAP composite hydrogel fostered osteogenesis in bone marrow mesenchymal stem cells (BMSCs) and angiogenesis in endothelial progenitor cells (EPCs). In parallel, the biological studies in rats demonstrated the composite hydrogel's potent ability to advance the healing of cranial bone flaws. Importantly, the composite hydrogel of USCEXOs/GelMA-HAMA/nHAP was found to facilitate the creation of H-type vessels within the bone regeneration area, thus significantly improving the therapeutic effect. Our investigation's conclusions reveal that this controllable and biocompatible USCEXOs/GelMA-HAMA/nHAP composite hydrogel is potentially effective in driving bone regeneration through the interplay of osteogenesis and angiogenesis.
Elevated glutamine demand and susceptibility to depletion are hallmarks of triple-negative breast cancer (TNBC), a cancer type characterized by unique glutamine addiction. Glutamine's hydrolysis into glutamate by glutaminase (GLS) is essential for the generation of glutathione (GSH). Accelerating TNBC proliferation is a critical downstream consequence of this glutamine metabolic pathway. read more Hence, manipulation of glutamine metabolism may offer potential treatments for TNBC. While GLS inhibitors show promise, their impact is impeded by glutamine resistance and their instability and insolubility. read more Accordingly, the aim of optimizing TNBC therapy is served by a synchronized glutamine metabolic intervention. Unfortunately, no such nanoplatform has come to fruition. We have developed a self-assembled nanoplatform (BCH NPs) that combines the GLS inhibitor Bis-2-(5-phenylacetamido-13,4-thiadiazol-2-yl)ethyl sulfide (BPTES) and the photosensitizer Chlorin e6 (Ce6) with a human serum albumin (HSA) shell. This nanoplatform effectively harmonizes glutamine metabolic intervention, demonstrating improved TNBC treatment. Glutathione (GSH) production was hampered by BPTES, which inhibited GLS activity and blocked glutamine metabolic pathways, ultimately augmenting the photodynamic action of Ce6. Ce6's impact on tumor cells involved not only its direct killing mechanisms via reactive oxygen species (ROS) overproduction, but also its depletion of glutathione (GSH), which disturbed redox balance, ultimately enhancing BPTES efficacy when glutamine resistance arose. With favorable biocompatibility, BCH NPs effectively eliminated TNBC tumors and suppressed their metastasis. read more Our research provides a unique perspective on glutamine metabolic intervention against TNBC using photodynamic therapies.
A factor associated with an increased burden of postoperative morbidity and mortality in patients is postoperative cognitive dysfunction (POCD). The inflammatory response, triggered by excessive reactive oxygen species (ROS) production in the postoperative brain, plays a critical role in the etiology of postoperative cognitive dysfunction (POCD). Despite this, no conclusive strategies to forestall POCD have thus far been devised. Importantly, the effective passage through the blood-brain barrier (BBB) and the preservation of life within the body are major challenges to preventing POCD when employing traditional reactive oxygen species scavengers. The co-precipitation method was used to synthesize mannose-coated superparamagnetic iron oxide nanoparticles, abbreviated as mSPIONs.